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Coaxial Airflow 2D Planar Simulation of Millifluidic Plant-Based Caviar Generator

Penjit Srinophakun, Anusith Thanapimmetha, Nutchapon Chiarasumran, Maythee Saisriyoot, Kittamet Chuwongbandith, Thongchai Rohitatisha Srinophakun


Millifluidic plant-based caviar generator was investigated. Effects of parameters; continuous phase flow rate, dispersed phase flow rate, and dispersed phase aperture diameter on the equivalent diameter, degree of spherical shape, and generation rate in a coaxial airflow alginate droplet generator were examined using a computational fluid dynamics (CFD) simulation program. A 2D planar simulation together with the volume of fluid (VOF) was applied to describe the phenomenon of droplet generation. Results showed that increasing the continuous phase flow rate yielded a decrease in equivalent diameter but an increase in droplet generation rate and an increase in the degree of spherical shape. Increasing the dispersed phase flow rate yielded a decrease in the degree of spherical shape but a significant increase in the droplet generation rate as well as a slight increase in equivalent diameter. Increasing the dispersed phase aperture diameter yielded an increase in equivalent diameter but a decrease in droplet generation rate and degree of spherical shape. Overall, the device could generate from 1,400–9,000 drops per hour with around 2.3–4.0 mm in size.


[1] P. Bronzi, H. Rosenthal, and J. Gessner, “Global sturgeon aquaculture production: An overview,” Journal of Applied Ichthyology, vol. 27, no. 2, pp. 169–175, 2011.


[2] M. S. Chebanov, S. B. Podushka, E. I. Rachek, D. Y. Amvrosov, and Y. G. Merkulov, “Hybrids of the Siberian Sturgeon,” in The Siberian Sturgeon (Acipenser baerii, Brandt, 1869) Volume 2 – Farming. Cham: Springer, pp. 289–326, 2018.


[3] L. J. Graham and B. R. Murphy, “The decline of the beluga sturgeon: A case study about fisheries management,” Journal of Natural Resources and Life Sciences Education, vol. 36, no. 1, pp. 66–75, 2007.


[4] A. Raposo, H. A. Alturki, R. Alkutbe, and D. Raheem, “Eating Sturgeon: An Endangered Delicacy,” Sustainability, vol. 15, no. 4, p. 3511, 2023.


[5] D. L. Scarnecchia, Y. Lim, L. F. Ryckman, K. M. Backes, S. E. Miller, R. S. Gangl, and B. J. Schmitz, “Virtual population analysis, episodic recruitment, and harvest management of paddlefish with applications to other acipenseriform fishes,” Reviews in Fisheries Science & Aquaculture, vol. 22, no. 1, pp. 16–35, 2014.


[6] M. I. Mityagina, O. Y. Lavrova, and A. G. Kostianoy, “Main pattern of the caspian sea surface oil pollution revealed by satellite data,” Ecologica Montenegrina, vol. 25, pp. 91–105, 2019.


[7] M. A. J. Shaikh, K. S. Alharbi, W. H. Almalki, S. S. Imam, M. Albratty, A. M. Meraya, S. I. Alzarea, I. Kazmi, F. A. Al-Abbasi, O. Afzal, A. S. A. Altamimi, Y. Singh, S. K. Singh, K. Dua, and G. Gupta, “Sodium alginate based drug delivery in management of breast cancer,” Carbohydrate Polymers, vol. 292, 2022, Art. no. 119689.


[8] N. M. Sanchez-Ballester, B. Bataille, and I. Soulairol, “Sodium alginate and alginic acid as pharmaceutical excipients for tablet formulation: Structure-function relationship,” Carbohydrate Polymers, vol. 270, 2021, Art. no. 118399.


[9] M. F. Azhar, M. S. Haris, I. Mohamad, M. N. S. N. Ismadi, A. A. H. A. Yazid, S. R. Rahman, and N. H. M. Azlan, “Optimisation of alginate-pectin bead formulation using central composite design guided electrospray technique,” International Food Research Journal, vol. 28, no. 4, pp. 860–870, 2021.


[10] L. H. Pignolet, A. S. Waldman, L. Schechinger, G. Govindarajoo, J. S. Nowick, and T. Labuza, “The alginate demonstration: Polymers, food science, and ion exchange,” Journal of Chemical Education, vol. 75, no. 11, 1998, doi: 10.1021/ ed075p1430.


[11] S. Patel, N. Scott, K. Patel, V. Mohylyuk, W. J. McAuley, and F. Liu, “Easy to swallow “Instant” jelly formulations for sustained release gliclazide delivery,” Journal of Pharmaceutical Sciences, vol. 109, no. 8, pp. 2474–2484, 2020.


[12] L. P. H. Bastos, J. Vicente, C. H. C. Santos, M. G. Carvalho, and E. E. Garcia-Rojas, “Encapsulation of black pepper (Piper nigrum L.) essential oil with gelatin and sodium alginate by complex coacervation,” Food Hydrocolloids, vol. 102, 2020, Art. no. 105605.


[13] D. Lewińska, J. Bukowski, M. Kożuchowski, A. Kinasiewicz, and A. Weryński, “Electrostatic microencapsulation of living cells,” Biocybernetics and Biomedical Engineering, vol. 28, pp. 69–89, 2008.


[14] H. Watanabea, T. Matsuyama, and H. Yamamoto, “Experimental study on electrostatic atomization of highly viscous liquids,” Journal of Electrostatics, vol. 57, no. 2, pp. 183–197, 2003.


[15] M. Whelehan and I. W. Marison, “Microencapsulation using vibrating technology,” Journal of Microencapsulation, vol. 28, no. 8, pp. 669–688, 2011.


[16] Y. Zhou, S. Kajiyama, H. Masuhara, Y. Hosokawa, T. Kaji, and K. Fukui, “A new size and shape controlling method for producing calcium alginate beads with immobilized proteins,” Journal of Biomedical Science and Engineering, vol. 02, pp. 287–293, 2009.


[17] S. Koch, C. Schwinger, J. Kressler, C. Heinzen, and N. G. Rainov, “Alginate encapsulation of genetically engineered mammalian cells Comparison of production devices, methods and microcapsule characteristics,” Journal of Microencapsulation, vol. 20, no. 3, pp. 303–316, 2003.


[18] L. Martín-Banderas, A. M. Gañán-Calvo, and M. Fernández-Arévalo, “Making drops in microencapsulation processes,” Letters in Drug Design & Discovery, vol. 7, no. 4, pp. 300–309, 2010.


[19] W. J. Aljohani, l. wenchao, M. W. Ullah, X. Zhang, and G. Yang, “Application of sodium alginate hydrogel,” IOSR Journal of Biotechnology and Biochemistry, vol. 03, no. 3, pp. 19–31, 2017.


[20] M. Workamp, S. Alaie, and J. A. Dijksman, “Coaxial air flow device for the production of millimeter-sized spherical hydrogel particles,” Review of Scientific Instruments, vol. 87, no. 12, 2016, Art. no. 125113.


[21] G. V. Theodorakopoulos, F. K. Katsaros, S. K. Papageorgiou, M. Beazi-Katsioti, and G. E. Romanos, “Engineering commercial TiO2 powder into tailored beads for efficient water purification,” Materials (Basel), vol. 15, no. 1, p. 326, 2022.


[22] R. K. Reddy, J. Gupta, and P. Izharuddin, “Alginate microspheres: The innovative approaches to production of the microbeads/ micro-particles,” Journal of Drug Delivery and Therapeutics, vol. 9, no. 4-s, pp. 774–781, 2019.


[23] T. Andersen, P. Auk-Emblem, and M. Dornish, “3D cell culture in alginate hydrogels,” Microarrays (Basel), vol. 4, no. 2, pp. 133–161, 2015.


[24] D. Lee, S. E. Greer, M. A. Kuss, Y. An, and A. T. Dudley, “3D printed alginate bead generator for high-throughput cell culture,” Biomed Microdevices, vol. 23, no. 2, p. 22, 2021.


[25] V. Kunopagarnwong, T. Rohitatisha Srinophakun, T. Sritaweewat, and Y. Chisti, “Design of a stacked-layer tubular photobioreactor for microalgae cultivation,” KMUTNB International Journal of Applied Science and Technology, vol. 8, no. 3, pp. 179–184, 2015.


[26] F. Guo and B. Chen, “Numerical study on taylor bubble formation in a micro-channel T-junction using VOF method,” Microgravity Science and Technology, vol. 21, no. S1, pp. 51–58, 2009.


[27] M. W. Weber and R. Shandas, “Computational fluid dynamics analysis of microbubble formation in microfluidic flow-focusing devices,” Microfluidics and Nanofluidics, vol. 3, no. 2, pp. 195–206, 2006.


[28] F. Mardani, S. Falahatian, and M. Taghipoor, “Mapping flow-focusing microfluidic droplet formation to determine high-throughput droplet generation configurations,” Results in Engineering, vol. 18, 2023, Art. no. 101125.


[29] Ansys Fluent 14.0 Theory Guide, Ansys, Pennsylvania, USA, 2011.


[30] T. Tate, “XXX. On the magnitude of a drop of liquid formed under different circumstances,” The London, Edinburgh, and Dublin Philosophical Magazine and Journal of Science, vol. 27, no. 181, pp. 176–180, 1864.


[31] W. D. Harkins and F. E. Brown, “The determination of surface tension (free surface energy) and the weight of falling drops: The surface tension of water and benzene by the capillary height method,” Journal of the American Chemical Society, vol. 41, no. 4, pp. 499–524, 1919.


[32] J. Yao, F. Lin, H. S. Kim, and J. Park, “The effect of oil viscosity on droplet generation rate and droplet size in a T-junction microfluidic droplet generator,” Micromachines (Basel), vol. 10, no. 12, p. 808, 2019.


[33] M. Rahimi, A. Shams Khorrami, and P. Rezai, “Effect of device geometry on droplet size in co-axial flow-focusing microfluidic droplet generation devices,” Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol. 570, pp. 510–517, 2019.


[34] C. Deng, H. Wang, W. Huang, and S. Cheng, “Numerical and experimental study of oil-in-water (O/W) droplet formation in a co-flowing capillary device,” Colloids and Surfaces A: Physicochemical and Engineering Aspects, vol. 533, pp. 1–8, 2017.

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DOI: 10.14416/j.asep.2024.05.002


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